Of these patients, 80% had PH according to the new definition, of whom 211 patients had mPAP > 20 mmHg but 20 mmHg and PAWP ≤ 15 mmHg) and patients with combined pre- and post-capillary PH (mPAP > 20 mmHg, PAWP > 15 mmHg, and PVR ≥ 3 WU) showed higher mean TRG and TRG/RVOT AT ratio and lower mean TAPSE/TRG and RVOT AT than patients with post-capillary PH alone (mPAP > 20 mmHg, PAWP > 15 mmHg, and PVR < 3 WU Table 1). 2.2 Echocardiographyīetwpatients with available echocardiographic and RHC data were included in the Giessen PH Registry because of suspected PH ( Fig. 1). Information on survival status was obtained in December 2020. Final diagnoses were made by the local multidisciplinary board. The investigation complies with the principles outlined in the Declaration of Helsinki and was approved by the ethics committee of the Faculty of Medicine at the University of Giessen (Approval No. An external validation cohort comprised of 703 from the Hannover PH centre (see below). All participating patients gave written informed consent to be enrolled in the Giessen PH Registry. All patients were transferred to our expert centre either by a family physician or by a specialist physician because of unclear symptoms (such as dyspnoea, fatigue, chest pain, or oedema) leading to a suspicion of PH. ] between 1 January 2008 and 31 December 2018 were included in this retrospective analysis (HG, AY, NS, FG, WS, MJR, KT, and HAG had access to the Giessen PH Registry). The Lancet Regional Health – Western Pacific.The Lancet Regional Health – Southeast Asia.The Lancet Gastroenterology & Hepatology.
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